A two-car crash closed part of Highway 246 Saturday afternoon between Lompoc and Buellton.
Santa Barbara County Fire officials responded to a call at 4:09 p.m. of an offset head-on collision between two cars.
Officials report three patients on-scene, including one with major injuries who needed to be extricated.
A helicopter has been dispatched to lift them to Santa Barbara Cottage Hospital.
This is a developing story and will be updated as more information becomes available.