Caltrans will be working on southbound Highway 101 near the Cuesta Grade between Atascadero and San Luis Obispo on Thursday until 4 p.m.
There is a one-lane closure during this vegetation control work.
This work will continue Friday, from 10 a.m. to 3 p.m.
Caltrans and CHP ask drivers to please give themselves extra time for their commute as there will be delays.