California Highway Patrol responded to reports of a crash at around 2:15 a.m. Thursday.
It happened on Highway 101 southbound near the Dos Pueblos Canyon Road off-ramp.
When they arrived officers say they found a single vehicle crashed off the road into a palm tree.
According to CHP, two females were in the car and one was ejected sustaining major injuries.
CHP said alcohol was a factor in the cause of the crash.