Southbound Highway 101 near Avila Beach was closed after a multi-vehicle crash Monday night.
Police responded to the crash around 10:22 p.m. at the San Luis Bay Dr.
Officials say that two vehicles were involved, including one that rolled over.
According to CHP, the driver of a Toyota Corolla was arrested for DUI.
A driver and passenger of a Honda Civic were transported to a hospital with minor injuries.
Both lanes of traffic have now been opened on Highway 101 and both cars have been removed from the highway.
