The Centers for Disease Control and Prevention says the death toll from lung illness associated with the use of e-cigarette has risen to five.
These deaths have been confirmed in California, Illinois, Indiana, Minnesota and Oregon, according to the CDC website.
The Los Angeles County Department of Public Health recorded and is currently investigating the fifth death, says the New York Times.
As of Sept. 6, more than 450 illnesses tied to vaping have been reported to the CDC from 33 states and one U.S. territory -- and that number is expected to rise.
The CDC says they are looking into several chemicals found in vape products, including tetrahydrocannabinol (THC) and vitamin E acetate, to find out "what is making people sick," says the director for the CDC.
State and federal health officials are advising people who use e-cigarettes to consider stopping using them altogether.
This story is developing. We will provide updates as more information becomes available.