Highway 41 is fully reopened between Highway 46 and Highway 133 as of Tuesday night.
On Sunday a rockslide caused a closure in both directions connecting San Luis Obispo County to California's I-5 corridor.
The slide occurred along a five-mile segment of the highway about 10 minutes north of Cholame.
Caltrans officials say crews installed concrete barriers topped with protective fencing and re-striped the road.
They say work will continue in the area behind barriers over the next month depending on the weather.
