UPDATE (12:15 p.m.) – All lanes of Highway 101 have reopened.
UPDATE: (11:45 a.m.) – Tow trucks were on scene preparing to move the vehicles as of 11:45 a.m.
CHP says they are investigating how the driver of a white Honda ended up heading northbound in the southbound lanes.
She and the two people in a Gold Lexus all complained of minor to moderate injuries, according to CHP.
The highway was expected to reopen by 12:15 p.m.
ORIGINAL STORY: A head-on crash in Santa Maria shut down a portion of Highway 101 Thursday morning.
It happened at about 10:45 a.m. in the southbound lanes just south of the Betteravia Road offramp.
The highway in the area is closed along with the Betteravia onramp to southbound Highway 101.
The crash reportedly left two people trapped and their vehicle upside down, according to the California Highway Patrol. Officers say a witness reported one of the vehicles was heading the wrong way prior to the crash.
No word on the extent of injuries but an ambulance has been requested at the scene.
This is a developing story and will be updated as information becomes available.