UPDATE: As of 3:30 p.m. all lanes are back open and the crash scene is clear.
CAL FIRE SLO says three people were involved in the crash. They suffered minor and moderate injuries.
California Highway Patrol is responding to a single vehicle crash Friday afternoon in San Luis Obispo.
The crash happened on southbound Highway 101 near the San Luis Bay Drive off-ramp.
According to CHP, the crash happened at around 2:50 p.m. with a single vehicle rollover into the center divide.
As of 3:00 p.m., there are no reports of any injuries.
A KSBY news crew is headed to the scene. Check back for more details.