UPDATE: As of 3:30 p.m. all lanes are back open and the crash scene is clear.
CAL FIRE SLO says three people were involved in the crash. They suffered minor and moderate injuries.
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California Highway Patrol is responding to a single vehicle crash Friday afternoon in San Luis Obispo.
The crash happened on southbound Highway 101 near the San Luis Bay Drive off-ramp.
According to CHP, the crash happened at around 2:50 p.m. with a single vehicle rollover into the center divide.
As of 3:00 p.m., there are no reports of any injuries.
A KSBY news crew is headed to the scene. Check back for more details.