Emergency crews were responding to a crash on Highway 135 in Santa Maria Tuesday morning.
It happened shortly after 9:30 a.m. near Preisker Lane and Holiday Inn.
According to initial reports from the California Highway Patrol, two vehicles were involved and one was on its roof.
The driver at fault was reported to be from out of town and was lost. Santa Maria Police say the driver got off the freeway then back on and failed to yield, causing a vehicle to roll over.
Police say the driver at fault experienced minor injuries and reported pain in his leg, but was transported to Marian Regional Medical Center out of an abundance of caution.
The northbound and southbound Highway 101 off-ramps were closed as of 10:04 a.m.
No alcohol or drugs were involved in the crash.