Orcutt Road was closed just outside the San Luis Obispo city limit on Wednesday after a pedestrian was struck and killed in a vehicle collision.
It happened at about 4:15 p.m. near La Lomita Way.
According to the California Highway Patrol, the female pedestrian was struck by a San Luis Obispo County Animal Services vehicle and died at the scene.
The CHP said the road would remain closed for an undetermined time.